Note: Answer keys are given at the end of the MCQs.
981. A drug substance is formulated into suppository dosage form according to the following formula;
Drug Concentration ...... 3.5 %
Cocoa butter base to make ...... 1 gram
Now the question is, in order to make a batch of 40,000 suppositories, how many grams of the drug should be used?
a- 600
b- 1400
c- 2800
d- 4000
e- 5000
982. Choose the one statement that correctly depicts the function of the alcohol dehydrogenase enzymes in humans?
a- accelerates the oxidation of alcohol
b- accelerates the reduction of alcohol
c- accelerates the hydrolysis of alcohol
d- accelerates the acetylation of alcohol
e- accelerates the glucuronidation of alcohol
983. Altering the structure of a drug substance has an impact on its biological activity. What will happen if the hydroxyl group is removed from the aromatic ring in the epinephrine structure?
a- loss of É‘-1 activity
b- increased É‘-1 selectivity
c- loss of β-1 activity
d- increased β-1 selectivity
e- conversion of epinephrine into norepinephrine
984. According to WHO, it is estimated that 41 million children under the age of 5 years were overweight or obese in 2016. To refer to this condition, the term used is;
a- pandemic
b- incidence
c- endemic
d- prevalence
e- epidemic
985. Capsule shells are made with the material called gelatin which belongs to the biochemical class of;
a- carbohydrate
b- lipoprotein
c- glycolipid
d- lipid
e- protein
986. Which research study design cannot be used to determine whether a particular exposure caused the disease or not?
a- case-control study
b- cohort study
c- randomized controlled trails
d- cross-sectional study
e- non-randomized controlled trails
987. A pharmaceutical company receives a manufacturing order for paracetamol syrup. The client wants 60ml bottles Using 3.6 kg of paracetamol, how many bottles of 120mg/5ml strength of the required syrup would be prepared?
a- 500 bottles
b- 1500 bottles
c- 2500 bottles
d- 3500 bottles
e- 5000 bottles
989. The endothelium-derived relaxing factor, nitric oxide is synthesized from which amino acid in our bodies?
a- histidine
b- lysine
c- leucine
d- arginine
e- tryptophan
990. Medications are given along with their most common side effect. Identify the one option that is not a correct match?
a- Metronidazole: metallic taste
b- Co-amoxiclav: diarrhea
c- Nitrates: headache
d- Pioglitazone: hyperglycemia
e- Propranolol: bradycardia
991. Trifluridine 1% ophthalmic solution contains 'thimerosal' as an excipient. This compound in the formulation functions as;
a- viscosity enhancer
b- preservative
c- solubility enhancer
d- tonicity agent
e- pH adjusting agent
992. For a patient with COPD, the doctor has prescribed salbutamol aerosol and beclomethasone aerosol both to be inhaled 4 times daily. As a pharmacist, how will you counsel this patient regarding the intake of these aerosols?
a- inhale beclomethasone immediately after salbutamol
b- inhale salbutamol immediately after beclomethasone
c- inhale beclomethasone 10 minutes after salbutamol
d- inhale beclomethasone 10 minutes before salbutamol
e- just inhale both aerosols 4 times daily at any convenient time
993. Which stability problem is encountered during the storage of cocoa butter suppositories?
a- blooming
b- hardening
c- hygroscopicity
d- brittleness
e- volume contraction
994. The type of epidemiological study in which neither the researcher assigns any exposures nor there is a comparison group is called;
995. Which of the following is NOT a feature of celiac disease?
a- it is an autoimmune disorder
b- can be triggered by a protein called gluten
c- primarily affects the large intestine
d- classic symptoms are bloating and gas
e- impaired ability of the body to absorb nutrients
996. Some drugs are administered as a racemic mixture, meaning their preparation is a mixture of their isomers. Which of the following medicinal agents is NOT administered as a racemate?
a- omeprazole
b- esomeprazole
c- propranolol
d- salbutamol
e- secobarbital
997. Aldosterone exerts its action by acting at which specific site in the nephron structure?
a- Bowman's capsule
b- primary convoluted tubule
c- thick ascending loop of Henle
d- thin descending loop of Henle
e- distal convoluted tubule
998. The chemical reaction shown below is an example of;
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999. Recalling the knowledge of pharmacy subjects, opt out the one statement that is INCORRECT?
a- the wavelength range for UV in UV-Visible spectroscopy is 400 to 700nm
b- TT vaccine is recommended during the first pregnancy in women
c- water hardness is the result of calcium and magnesium ions concentration
d- the term 'cold place' on medicines refers to the temperature between 2-8°C
e- cisplatin is known to induce Fanconi syndrome
1000. In medical research, which studies design is considered to be the “gold standard” for testing the safety and efficacy of new drugs and treatments?
a- randomized controlled trails
b- prospective cohort study
c- a case-control study
d- cross-sectional study
e- non-randomized controlled trails
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