- The most prominent and dose related side effect of salbutamol is Β2-mediated skeletal muscle tremors.
- In a patient of bronchial asthma, Salbutamol is the fastest acting inhaled bronchodilator, which aborts or terminates asthma attacks.
- Leukotriene (cys LT1, i.e. Cysteinyl leukotriene receptor 1) receptor antagonists is the class of drugs that are clinically beneficial in bronchial asthma.
- Salmeterol is a long-acting selective β-2 agonist bronchodilator.
- Theophylline use in asthma has declined because of narrow safety margin.
- Relatively higher dose of theophylline is required to attain therapeutic plasma concentration in smokers.
- Bambuterol is a long-acting β adrenoceptor agonist (LABA) used in the treatment of asthma.
- Bambuterol is an orally acting bronchodilator, a prodrug of terbutaline and inhibits the enzyme pseudocholinesterase.
- Methylxanthines exert the following actions at cellular or molecular level: causes intracellular release of Ca2+, blockade of adenosine receptors and inhibition of phosphodiesterase (PDE) enzyme which breaks down cAMP into AMP.
- Caffeine is a commonly used neurostimulant that also produces cerebral vasoconstriction by antagonizing adenosine receptors which reduces cerebral blood flow.
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Pharmacy Exam Points (to remember)... Set 26
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