Pharmacy Exam Points (to remember)... Set 10

1. Cysteinyl leukotrienes (CysLTs) are a family of inflammatory mediators synthesized from arachidonic acid by a variety of cells, including mast cells, eosinophils, basophils, and macrophages. 
2. Cysteinyl leukotrienes (LT-C4/D4) produce long lasting bronchoconstriction.
3. The most prominent action of leukotriene B4 is the chemotaxis of neutrophils and monocytes.
4. Montelukast blocks the action of the autacoid: Leukotriene C4/D4.
5. Cervical priming with prostaglandin results in softening of cervix.
6. Prostaglandin E2 is used for cervical priming to facilitate labour.
7. Prolonged airway hyperreactivity (bronchoconstriction) is characteristically caused by PAF, platelet activating factor.
8. The actions of platelet activating factor includes increased capillary permeability, vasodilatation, erosion of gastric mucosa.
9. Paracetamol is an analgesic that lacks antiinflammatory action.
10. Paracetamol and nefopam are nonopioid analgesics that do not inhibit PG synthesis and have no/weak antiinflammtory property.