Pharmacy Exam Points (to remember)... Set 11

1. All nonopioid analgesics lack dependence producing action.
2. Aspirin produces analgesia by preventing sensitization of peripheral pain receptors and raising pain threshold at subcortical level.
3. Prostaglandin synthesis inhibition causes prolongation of bleeding time, prolongation of labour and gastric mucosal damage but NOT prolongation of prothrombin time.
4. Inhibition of prostaglandin synthesis underlie the following actions of aspirin, i.e. analgesia, closure of patent ductus arteriosus and bleeding tendency but does not underlie the hyperventilation.
5. Selective COX-2 inhibitors differ from non-selective COX-1/COX-2 inhibitors in that they do not inhibit platelet aggregation.
6. Cimetidine inhibit liver enzymes while Rifampicin induces liver enzymes.
7. Pseudomembranous colitis (PMC) is inflammation in the colon that happens when there's too much of certain bacteria in the system. The most common bacterium that causes PMC is Clostridium difficile. PMC is also called antibiotic-associated colitis or C. difficile colitis. Most of the time, it's a side effect of taking antibiotics. 
8. To treat Pseudomembranous colitis, depending on the condition of the patient, doctors will most often use metronidazole, vancomycin, fidaxomicin or a combination of these.
9. Streptokinase, a fibrinolytic drug, is indicated for the treatment of pulmonary embolism.
10. In asthmatic patients, NSAIDs are not well-tolerated as they can deteriorate the respiratory function. However, Paracetamol is indicated generally as an analgesic for asthamatics.