Saudi Pharmacist Licensing Exam Questions

Saudi Prometric SPLE exam preparation MCQs

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176) The illness of diphtheria, primarily affects which part of the body?
A) Small intestine
B) Large intestine
C) Respiratory system
D) Bloodstream
E) Stomach







177) Which class of antidepressants is generally less likely to exacerbate seizure activity compared to other classes of  antidepressants?

A) Tricyclic antidepressants (TCAs)
B) Selective serotonin reuptake inhibitors (SSRIs)
C) Monoamine oxidase inhibitors (MAOIs)
D) Serotonin-norepinephrine reuptake inhibitors (SNRIs)
E) Atypical antidepressants







178) Raised, itchy, red patches with central clearing are the characteristic features of conditions like;
a- herpes simplex virus infection
b- tinea corporis
c- contact dermatitis
d- psoriasis or eczema
e- pemphigus vulgaris








179) A medical term that refers to an abnormally high white blood cell count, is?

A) Neutropenia
B) Leukopenia
C) Leukocytosis
D) Thrombocytosis
E) Agranulocytosis






180) A patient experiences hypertensive crisis requiring rapid lowering of blood pressure. Which of the following medications is MOST LIKELY to be administered intravenously (IV) for its fast-acting vasodilatory effect?

A) Enalaprilat
B) Hydralazine
C) Fenoldopam
D) Labetalol
E) Nitroglycerin







181) Vonoprazan belongs to which class of medications used to treat gastrointestinal conditions?

A) Antacids
B) H2-receptor antagonists
C) Proton pump inhibitors
D) Antidiarrheal medications
E) Probiotics






182) Which enzyme is primarily responsible for reducing hydrogen peroxide in cells?
a. Catalase
b. Superoxide dismutase
c. Glutathione peroxidase
d. Lipoxygenase
e. Cyclooxygenase






183) Which vitamin acts as a potent lipid-soluble antioxidant, protecting membranes from oxidative damage?
a. Vitamin A
b. Vitamin C
c. Vitamin D
d. Vitamin E
e. Vitamin K





184) To correct hypomagnesemia, which ion is typically administered to patients?
a. Calcium
b. Magnesium
c. Potassium
d. Sodium
e. Chloride







185) The immunoglobulin that activates the complement system is:
a- immunoglobulin D
b- immunoglobulin M
c- immunoglobulin G
d- immunoglobulin A
e- immunoglobulin E






186) In the case of hyperkalemia, which of the following is often used to help lower potassium levels?
a. Insulin and glucose
b. Calcium gluconate
c. Sodium bicarbonate
d. All of the above
e. None of the above







187) Which part of the brain is primarily responsible for the release of dopamine, influencing reward and pleasure centers?
a. Amygdala
b. Hippocampus
c. Prefrontal cortex
d. Substantia nigra
e. Hypothalamus






188) Which medication is commonly used to treat bradycardia by increasing heart rate?
a. Atropine
b. Lidocaine
c. Amiodarone
d. Digoxin
e. Furosemide







189) Endorphins are most closely related to which type of sensation?
a. Pain
b. Vision
c. Taste
d. Hearing
e. Balance







190) For the treatment of acute hypercalcemia, which of the following is often administered?
a. Thiazide diuretics
b. Loop diuretics
c. Calcium supplements
d. Vitamin D
e. Potassium chloride








191) Which enzyme breaks down acetylcholine in the synaptic cleft, terminating the signal transmission?
a. Monoamine oxidase
b. Catechol-O-methyltransferase
c. Acetylcholinesterase
d. Tyrosine hydroxylase
e. Glutaminase








192) In cases of digoxin toxicity, which of the following treatments is used to bind and inactivate the drug?
a. Digoxin immune fab
b. Activated charcoal
c. Beta-blockers
d. Calcium channel blockers
e. Sodium polystyrene sulfonate







193) To manage acute hyponatremia, which solution is typically administered?
a. Hypertonic saline
b. Hypotonic saline
c. Isotonic saline
d. Dextrose 5% in water
e. Lactated Ringer's solution






194) Which of the following drugs is used to counteract the effects of potassium-sparing diuretics and prevent hyperkalemia?
a. Furosemide
b. Spironolactone
c. Amiloride
d. Hydrochlorothiazide
e. Acetazolamide





195) Which type of receptor is primarily responsible for the effects of opioid analgesics?
a. Muscarinic receptors
b. NMDA receptors
c. GABA receptors
d. Nicotinic receptors
e. Mu receptors








196) Which of the following statements about transcription is accurate?
a. After initiation, the next step in transcription is termination
b. The enzyme initiating transcription is DNA polymerase
c. The enzyme initiating transcription is RNA polymerase
d. During transcription, the genetic code in tRNA is converted into protein structure
e. Transcription involves the splicing of exons







197) What is the function of a promoter in transcription?
a. To terminate transcription
b. To bind RNA polymerase and initiate transcription
c. To splice exons together
d. To translate mRNA into protein
e. To replicate the DNA template






198) Which of the following modifications occurs to eukaryotic pre-mRNA before it becomes mature mRNA?
a. Addition of a 5' cap.
b. Addition of a poly-A tail.
c. Splicing of introns.
d. All of the above.
e. None of the above.







199) During transcription in eukaryotic cells, which of the following processes removes non-coding sequences from the pre-mRNA transcript?
a. Capping
b. Polyadenylation
c. Splicing
d. Translation
e. Replication








200) To treat hypokalemia induced by cardiac glycosides, activation of the Na+-K+-ATPase pump is achieved by administering which chemical substance?
a. magnesium
b. potassium chloride
c. bicarbonate
d. insulin
e. vitamin D










176- C

177- B

178- d

179- C

180- B

181- C
Explanation:
  • Vonoprazan is a proton pump inhibitor (PPI). PPIs work by blocking the action of hydrogen-potassium ATPase (proton pump) in the stomach, which significantly reduces stomach acid production.
  • Antacids neutralize existing stomach acid but don't prevent its production.
  • H2-receptor antagonists work by reducing the amount of acid produced by stomach cells, but their effect is weaker than PPIs.
  • Antidiarrheal medications address diarrhea symptoms and don't directly affect stomach acid.
  • Probiotics are live bacteria that can improve gut health, but they don't target stomach acid production.

182- a. Catalase

183- d. Vitamin E

184- b. Magnesium

185- b- immunoglobulin M

186- d. All of the above

187- d. Substantia nigra

188- a. Atropine

189- a. Pain

190- b. Loop diuretics

191- c. Acetylcholinesterase

192- a. Digoxin immune fab

193- a. Hypertonic saline

194- a. Furosemide

195- e. Mu receptors

196- c. The enzyme initiating transcription is RNA polymerase

197- b. To bind RNA polymerase and initiate transcription.

198- d. All of the above

199- c. Splicing

200- b. potassium chloride