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Note: Answer keys are given at the end of the MCQs.

481. Breakbone fever is another name for;
a- malaria fever
b- typhoid fever
c- dengue fever
d- covid fever
e- ebola fever

482. Cisplatin is a potent chemotherapy agent used to treat a wide variety of malignancies but its repeated administration can cause renal toxicity. Which of the following agents can be used to counter this adverse situation?
a- amifostine
b- n-acetylcysteine
c- dimercaprol
d- deferiprone
e- Prussian blue

483. Methotrexate toxic effects can be reversed with;
a- levoleucovorin
b- sodium thiosulfate
c- sodium nitrite
d- atmoxetine
e- fingolimod

484. What is the best time to take folic acid supplement when taking methotrexate?
a- an hour before
methotrexate dose
b- along with the dose of methotrexate
c-
an hour after methotrexate dose
d-
the day after the methotrexate dose
e- at the end of methotrexate therapy

485. A treatment approved by the FDA for the treatment of plasma toxicity of
methotrexate in the context of kidney dysfunction;
a- glucarpidase
b- f
ingolimod
c- nalmefene
d- activated charcoal
e- pyridoxine

486. The toxic effects of antimalarial drug pyrimethamine can be dealt with by employing one of the following;
a- thiamine
b- riboflavin
c- niacin
d- pyridoxine
e- folinic acid

487. Normal pulse rate is;
a- 40 - 60 bpm
b- 60 - 80 bpm
c- 80 - 100 bpm
d- 80 -120 bpm
e- 60 - 100 bpm

488. Soy isoflavones exert their pharmacological action via;
a- mineralocorticoid receptor
b- histamine receptor
c- adrenergic receptor
d- estrogen receptor
e- NMDA receptor

489. Identify the pharmacokinetics statement that is NOT correct;

a- zero-order kinetics is a concentration-dependent process
b- half-life of a drug increases as volume of distribution increases
c-
half-life of a drug increases as clearance decreases
d- a lipophilic non-ionic drug will readily cross the blood-testes barrier
e- eyes, ears and nose are topical routes of administration

490. If the expiry of a drug is mentioned as June, 2025. Up til when can this drug be used without any worry?
a- 1st June 2025
b- 15th June 2025
c- 30th June 2025
d- 31st May 2025
e- the drug should not be used during the last days of its life

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Answer Keys
MCQ # - Correct option
481- c
482- a
483- a
484- d
485- a
486- e
487- e
488- d
489- a
490- c