Pharmacy Exam Points (to remember)... Set 23

1. Among the disease modifying antirheumatic drugs, fastest symptom relief is obtained with methotrexate (immunosuppressive drug).
2. Hyperuricaemia is produced by ethambutol, pyrazinamide and hydrochlorthiazide but not by sulfinpyrazone and probenecid which are uricosuric drugs.
3. Indomethacin (NSAID) is the first choice drug for acute gout.
4. NSAIDs are more commonly used than colchicine in acute gout because they are better tolerated.
5. The drug which is neither analgesic, nor antiinflammatory, nor uricosuric but is highly efficacious in acute gout is colchicine.
6. The most important dose-limiting adverse effect of colchicine is diarrhoea.
7. Probenecid is an oral uricosuric drug with no analgesic or anti-inflammatory actions.
8. Sulfinpyrazone is a uricosuric medication used to treat gout. It also sometimes is used to reduce platelet aggregation by inhibiting degranulation of platelets which reduces the release of ADP and thromboxane.
9. Allopurinol is a purine analog. It reduces the production of uric acid by competitively inhibiting the last two steps in uric acid biosynthesis that are catalyzed by xanthine oxidase.
10. Allopurinol lowers the plasma concentration of uric acid.