1. Probenecid plus Penicillins interaction is there. Probenecid inhibits the secretion of penicillins at kidneys by competing for active tubular secretion via the organic acid transporter and, thus can increase blood levels of penicillins.
2. The penicillins are excreted into breast milk.
3. Pseudomembranous colitis from Clostridium difficile and other organisms can occur with penicillin use.
4. Adverse effects with penicillin use are hypersensitivity, nephritis (esp. with Methicillin), blood disorders (decreased coagulation, cytopenias), neurotoxicity (seizures) due to GABA inhibition and diarrhea.
5. The early pregnancy uterus is sensitive to the oxytocic, Prostaglandin F2α.
6. Metabolic effects that generally attend antiinflammatory doses of aspirin includes, increased CO2 production, hepatic glycogen depletion, compensated respiratory alkalosis but not metabolic acidosis.
7. Increased occult blood loss in stools is seen at low (analgesic) doses of aspirin.
8. Aspirin reduces fever by enhancing cutaneous blood flow and inducing sweating and NOT by decreasing heat production in the body.
9. The isoenzyme cyclooxygenase-2 (COX-2) is expressed constitutively at the Juxtaglomerular apparatus.
10. Cephamycins is a naturally occurring family of beta-lactam cephalosporin-type antibiotics having a 7-methoxy group and possessing marked resistance to the action of beta-lactamases from gram-positive and gram-negative organisms.
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